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Common use

Brand Levitra was developed by the pharmaceutical company Bayer/GlaxoSmithKline and uses Vardenafil HCl as main component of the medication. Levitra is an oral drug used to treat erectile dysfunction. Sexual stimulation causes the production and release of nitric oxide from the nerves endings of the cavernous bodies of the penis hereby activating enzyme guanylate cyclase. Guanylate cyclase in its turn is responsible for production of cyclic guanosine monophosphate (cGMP). The cGMP causes widening and relaxation of the blood vessels carrying blood to the penis. Levitra prevents phosphodiesterase-5 enzyme from destroying cGMP and thus helps to support blood flow to the penis.

Dosage and direction

The recommended dose of Levitra is 10 mg per day taken an hour before intercourse. If no side effects are experienced the dosage can be increased up to 20 mg. In case of adverse effects the dose is reduced to 5 mg daily. Do not take more than one tab of Levitra a day.


Levitra has not been studied in people with cardiovascular disease, so it is preferable to avoid Levitra if in patients who have a stroke or heart failure, or a heart attack in history and especially within last six month. Before to take Levitra inform your doctor if you have kidney or liver problems, a bleeding disorder, stomach ulcer, or an inherited retinal disorder such as retinitis pigmentosa, allergic reaction to this medicine or any other medicines, deformation of the penis such as angulation, cavernous fibrosis (Peyronie's disease), as well as in diseases that contribute to the development of priapism (sickle-cell anemia, multiple myeloma, leukemia, or leukemia).


Levitra is contraindicated in patients with hypersensitivity to its ingredients, ones treated with organic nitrates, in patients under 16 y.o., or those who take HIV protease inhibitors such as indinavir and ritonavir.

Possible side effect

Levitra is usually well tolerated and side effects if occur are transient. The most frequent side effects are: headache, flushing (hyperemia of the person); frequent; dizziness, diarrhea phenomenon, nausea, nasal congestion. More rare and uncommon adverse effects are photosensitivity of skin, hypertension, back pain, watery eyes, hypotension, myalgia, priapism.

Drug interaction

Levitra's metabolism is inhibited by erythromycin, ketoconazole (Nizoral), itraconazole (Sporanox), indinavir (Crixivan) and ritonavir (Norvir). Levitra reduces the concentration of ritonavir and indinavir. In patients treated with nitrates Levitra may aggravate chest pain by increasing heart rate and lowering blood pressure. Levitra is able to exaggerate the blood pressure lowering effects of alpha-blocking drugs (terazosin or Hytrin). Levitra never should be administered in patients who are treated with organic nitrates.

Missed dose

Levitra is taken when needed but not more often than once daily so missed dose is not supposed.


Symptoms of overdose include pain in the back, jaw, arm, blindness, blurred vision, chest pain or discomfort, decreased vision, blurred vision.


Store at room temperature between 15-30 C (59-86 F) away from children, pets, moisture and sunlight.


We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.


Other names used:

  • CialisĀ®

Active Ingredients:

  • Tadalafil

How does Tadalafil work and what pharmaceutical group does it belong to?

Tadalafil is a reversable selective inhibitor of the specific phosphodiesterase type 5(PDE5) cGMP. When sexual excitement causes local release of NO, inhibiting of PDE5 by Tadalafil causes an increase of cGMP levels in the cavernous body of the penis. This causes smooth muscles to relax and increases blood flow to the penis. Tadalafil does not cause an erection without sexual stimulation.

Tadalafil acts within 36 hours and effect occurs in 16 minutes after the sexual excitement. Tadalafil does not cause changes in systolic and diastolic pressure and heart rate.

Tadalafil is availabla in the form of soft tablets that are dissolved directly under the tongue. This increases the bioavalability of the preparation.

Which conditions are treated with Tadalafil?

Tadalafil is indicated for the treatment of erectile dysfunction.

What should a patient know prior taking the medication?

Tadalafil is contraindicated in patients with hypersensitivity to any of the medication ingredients.

Tadalafil is not approved to treat females or children and adolescents under 18 years of age.

Tadalafil should not be taken in patients which take organic nitrates.

Tadalafil should be used with caution in:

  • Cardiovascular disease including recent heart attacks, strokes, high or low blood pressure, heart failure, abnormal heart rhythm
  • Liver and kidney diseases
  • Vision problems
  • Blood diseases including Sickle cell anemia, leukemia
  • Penis deformation
  • Multiple myeloma

Which adverse effects may manifest when using the medication?

The most common Tadalafil side effects are associated with blocking of PDE5. These are: headache, stuffy nose, nasal congestion, dizziness, drowsiness, upset stomach or dyspepsia, hot flushing, pain in the arms, legs and muscles.

In rare cases Tadalafil may cause: angina, high blood pressure, insomnia, blurred vision, migraines, problems with vision and hearing.

It is not necessary that the side effects will manifest in an individual but the possibility still exist. For more information please consult your health care provider.

Which groups of drugs or specific preparations may interact with Tadalafil?

The drug is affected by the following:

  • Alcoholic beverages
  • Alpha blockers
  • High blood pressure medicines
  • Antumycotics
  • Certain antibiotics
  • Grape fruit juice
  • Nitrates
  • Antivirals
  • Xantines(Theophylline)

Tell your doctor about all the herbal preparations as well as prescription drugs that you are currently taking even if they are not on the list.

Important information for the patient:

Tadalafil is supplied for individual use. Do not use it to treat other conditions not listed in the leaflet. Keep the product out of children reach. Do not reuse any disposable materials if supplied with the preparation.